Significant new developments as well as controversies have taken place in psychopharmacology during the past two years. This workshop addresses: potential problems with suicidality in children and teenagers treated with antidepressants, childhood onset bipolar disorder (differential diagnosis and treatment), new diagnostic criteria for bipolar spectrum disorders, new bipolar medications, empirically derived treatment guidelines for ADHD and for major depression, new studies on over-the-counter products such as St. John’s Wort, Omega-3 fatty acids, and SAM-e, and finally, the role of psychotropic drugs in protecting and healing the brain (neuro-protection).